32 results
diagnosis differential algorithm hemolysis management oncology pancytopenia rheumatology systemic classification extravascular generalized intravascular pruritus agglutinin aiha alkaline alp atlas autoimmune
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... Urobilinogen • + urinary ... #Hemolytic #Anemia ... #Differential #Causes ... #Workup #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... usually IgM) (e.g. primary ... differential #diagnosis #hematology ... #anemia
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Reticulocytosis • Primary ... Hypersplenism • Secondary ... Bleed • Hemolysis ... #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Warm AIHA • Cold ... • PCH • PNH ... anemia • ... #Hematology
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Autoimmune Hemolytic ... Anemia (AIHA) ... WARM AHA - Primary ... alpha-methyldopa COLD ... EBV • Viral PNA
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... Secondary Cold ... lymphoproliferative disorder Secondary ... anemia • Cold ... #anemia #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... iron deficiency, hemolysis ... Post-splenectomy Primary ... #hematology #secondary
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... platelet decrease - PNH ... Agglutination - Cold ... Diagnosis #Algorithm #workup ... #hematology #testing
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic ... • AIHA: warm, cold ... #Anemia #Differential ... classification #hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Asthma - COPD ... - Water - Pus ... Barre - ALS - Transverse ... myelitis • Hematology ... : - Anemia •
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