18 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Secondary ... Clinically Relevant HES ... suspect underlying hematologic ... Diagnosis and Treatment ... #HES #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
leakage of RBC's secondary ... Kasabach-Merritt syndrome ... deficiencies - PNH ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
 • Myocardium:
	- Heart failure
	- CAD/ACS
	- Valvulopathy
 • Electrical:
	-
Cardiovascular Causes ... - Water - Pus ... Hepatopulmonary syndrome ... Barre - ALS - Transverse ... myelitis • Hematology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Nail Disorders secondary ... Muehrcke's Lines - Transverse ... • Nephrotic syndrome ... #dermatology #Differential ... Diagnosis #Algorithm #causes
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... autoantibodies that will cause ... Puncture, EEG Treatment ... APS), Secondary ... #neurology #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... (HUS) • Other ... hemoglobinuria (PNH ... differential #diagnosis #hematology
Causes of Antibiotic Failure - Differential Diagnosis Framework
Diagnosis:
 • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Causes of Antibiotic ... NMS, serotonin syndrome ... Soon: Can take 48 hrs ... Tissue penetration (CNS ... to Treatment: Drug
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia Syndrome ... blood eosinophilia Secondary ... Causes: - Allergic ... Hypereosinophilia #Syndrome ... #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
+ Bleeding Treatment ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management ... #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Classified among the secondary ... nervous system (CNS ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology