22 results
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and permanent alopecia ... • May involve PNS ... neuropathy • Transverse ... • Nonscarring alopecia ... #Diagnosis #Rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Photosensitivity, Alopecia ... Positive in 60-80% of cases ... #Systemic #Erythematosus ... #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... Demyelinating Syndrome ... autoantibodies that will cause ... #rheumatology # ... cerebritis #diagnosis #management
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
erythematosus ... • Loose anagen syndrome ... • Discoid lupus ... erythematosus ... Diagnosis #Algorithm #causes
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
Disease: Discoid lupus ... erythematosus, ... : Lupus erythematosus ... , Loose anagen syndrome ... Scaling, pustules, crusts
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... #Systemic #Lupus ... #Erythematosus ... Summary #diagnosis #rheumatology ... #management
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... antiphospholipid syndrome ... S - Systemic Lupus ... Erythematosus ( ... #differential #hematology
Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
 • Myocardium:
	- Heart failure
	- CAD/ACS
	- Valvulopathy
 • Electrical:
	-
Cardiovascular Causes ... - Water - Pus ... Hepatopulmonary syndrome ... Barre - ALS - Transverse ... myelitis • Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
erythematosus ... nervous system (CNS ... erythematosus [ ... #Diagnosis #Management ... #Hematology #Rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... Erythematosus ( ... Photosensitivity, Alopecia ... comparison #table #rheumatology ... #diagnosis #management