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diagnosis hematology differential anemia algorithm management causes atlas macrocytic macrocytosis morphology oncology transfusion cirrhosis classification disease elevatedmcv hemolytic key liver
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... Decreased RBC ... Infiltration Increased RBC ... Thalassemia • RBC ... Disorder • RBC
ABO Blood Types and Transfusion Compatibility Table A Blood Type: • RBC Antigens: A • Antibodies: Anti-B
Type: • RBC Antigens ... Type: • RBC Antigens ... Type: • RBC Antigens ... Type: • RBC Antigens ... Compatibility #Table #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
(MCV): Average RBC ... wide range of RBC ... in peripheral blood ... High in acute blood ... Algorithm #Diagnosis #Workup
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
directed donations) - RBC ... Hct of 70-80% - RBC ... plasma, a few RBC ... ofplasma, a few RBC ... Contents #Volume #Hematology
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases Acanthocyte (spur cell), Basophilic stippling, Bite cell,
Pathologic Red Blood ... Cell (RBC) Morphologies ... cell, Other RBC ... Howell-Jolly bodies #RBC ... Microscopy #Pathology #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... RBC) Morphology ... Microcytic RBC: ... disease, McLeod blood ... Bite Cell RBC: G6PD
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... 3) Internal (RBC ... - Peripheral Blood ... Smear ↑ abnormal RBCs ... Differential #Diagnosis #hematology
Hematuria Workup and Diagnosis Algorithm • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup ... Urinalysis >3 RBCs ... (proteinuria, RBC ... Diagnosis #Algorithm #Workup ... #urology #blood
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Tests: • MCV/RBC ... - RBC ↓ in proportion ... carrying component of blood ... Fe #diagnosis #hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
- Fe/TlBC, MCV/RBC ... Causes: Chronic Blood ... TIBC Normal - MCV/RBC ... inclusions in RBC ... Algorithm #Causes #Hematology
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