55 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... • Autoimmune diseases ... Adult-onset Still disease ... chemotherapy, anti-CD20 (PTLD ... Lymphohistiocytosis #diagnosis #management
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Peripheral Smear ... Vasculitides, IBD, Celiac disease ... : Chronic infections ... pancreatitis, Post-surgical ... Others: Asplenia/post-splenectomy
Graves' Disease Treatment
Thionamides (mainly methimazole)
 • Chance of remission in up to 2 years
 • No
Graves' Disease ... (~40%) • Low cost ... mendesthiagob #Graves #Disease ... #Treatment #Management ... #endocrinology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Due to Viral infection ... Cold-induced symptoms - most ... IgM) • Blood smear ... Polyclonal IgM post ... infectious setting
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Chronic lung disease ... • Infectious ... other cancers: Most ... and M panel Management ... hematology #diagnosis #management
Hypocalcemia - Diagnosis and Management
PTH Independent (↑ PTH)
 • LOW VIT D
    -
Diagnosis and Management ... Activation: Liver disease ... , Kidney Disease ... - Iatrogenic (most ... #endocrinology
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary
Chagas disease (American trypanosomiasis) is an infectious
Diagnosis and Management ... trypanosomiasis) is an infectious ... family Route of infections ... positive serology, smear ... thick peripheral smears
Invasive Aspergillus (IA) - Diagnosis and Management
Aspergillus is ubiquitous in nature. Most invasive infections are caused
Diagnosis and Management ... Most invasive infections ... , Disseminated infection ... Diseases Fellows ... IA #Diagnosis #Management
Graves Disease - Autoimmune Hyperthyroidism
Epidemiology: Most common cause of hyperthyroidism, Incidence peaks at 30-50
Diagnosis: 
1 )
Graves Disease - ... Epidemiology: Most ... UTSWIMchief #Graves #Disease ... Hyperthyroidism #diagnosis #management ... #endocrinology
Ascites - Diagnostic Approach and Differential Diagnosis
The most common causes: cirrhosis, malignancy and heart failure. Approx
Diagnosis The most ... Physical Exam: 1) Most ... of underlying disease ... culture bottles (infection ... perforation), TB smear