71 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... extramedullary disease ... develop leukostasis syndrome ... • Peripheral smear ... • Tumor lysis syndrome
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Cold-induced symptoms - most ... IgM) • Blood smear ... Polyclonal IgM post ... infectious setting
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
: • Most common ... weeks without infection ... • Peripheral smear ... cells can indicate disease ... • Richter’s Syndrome
Post-Transplantation Lymphoproliferative Disorders (PTLD)
Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
Post-Transplantation ... hematopoietic cell ... , intensity of induction ... #Post #Transplantation ... oncology #diagnosis #management
Causes of Severe Aortic Regurgitation - Differential Diagnosis
Acute:
 • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Rupture, Acute Infective ... Valve Dysfunction, Post ... Salmonella), Giant Cell ... Arteritis, Behcet Syndrome ... Ehlers-Danlos Syndrome
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Peripheral Smear ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome ... pancreatitis, Post-surgical ... Others: Asplenia/post-splenectomy
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... ) (e.g. lupus, CLL ... antibiotics are the most ... spherocytosis) • Infections
Adjuvant therapies in critical care: steroids to treat infectious diseases
 - Severe Community Acquired Pneumonia
steroids to treat infectious ... diseases - Severe ... respiratory distress syndrome ... Corticosteroids #Adjuvant #InfectiousDiseases ... #Management #Treatment
Disseminated Gonococcal Infection - Diagnosis and Management Summary

Bacteremic spread of the Gram-negative diplococci Neisseria gonorrhoeae. History
Diagnosis and Management ... Arthritis-Dermatitis syndrome ... Purulent Arthritis Syndrome ... : • Most patients ... #Microbiology #InfectiousDiseases
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
lymphoma, B-cell ... • Autoimmune diseases ... Adult-onset Still disease ... chemotherapy, anti-CD20 (PTLD ... Lymphohistiocytosis #diagnosis #management