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diagnosis differential hematology treatment oncology microbiology algorithm classification dermatology neurology rheumatology fever workup anemia clinical hemeonc hemophagocytic hiv hlh lymphohistiocytosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... Malaise, bleeding, infections ... pain, bleeding, infections ... bruising, bleeding, infection ... • Peripheral smear
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... weeks without infection ... • Peripheral smear ... • Richter’s Syndrome ... syndrome • Smoldering
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome ... - Causes and Treatment ... macroglobulinemia (most ... transformation (CML ... Diagnosis #Treatment #Management
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Diagnosis • Infection ... Lemierre's syndrome ... malignancies: Lymphoma, Leukemia ... tumors: Renal cell ... carcinoma • Non-infectious
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute infection ... sarcoidosis) • Post-splenectomy ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... (CML) - Dr.
Ear Pain (Otalgia) - Differential Diagnosis Framework Primary Otalgia - Pain that originates from the ear
associated with infection ... by bacterial infections ... (90%), Fungal infections ... • Dental infections ... • Dental infections
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
Most invasive infections ... Rhinosinusitis, CNS infection ... , Disseminated infection ... systemic vori Infectious ... treatment #fungal #infectiousdiseases
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Leukemia, Tumour ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome ... Vasculitis • Infection
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... Acquired HLH: • Infections ... Still disease, Infection ... Drugs, Unknown cause ... Etiological+++: Anti-infectious
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... ) (e.g. lupus, CLL ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections
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