39 results
diagnosis hematology differential oncology treatment causes leukemia microbiology anemia blood chronic disease gastroenterology hemeonc hemolysis hemolytic hemophagocytic hlh lymphocytic lymphohistiocytosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... develop leukostasis syndrome ... • Peripheral smear ... • Tumor lysis syndrome ... #Leukemia #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Peripheral Smear ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome ... pancreatitis, Post-surgical ... Others: Asplenia/post-splenectomy
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... weeks without infection ... • Peripheral smear ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
Post-Transplantation ... hematopoietic cell ... , intensity of induction ... #Post #Transplantation ... oncology #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... IgM) • Blood smear ... Polyclonal IgM post ... malignancies -> CLL ... hemolytic #anemia #hematology
Disseminated Gonococcal Infection - Diagnosis and Management Summary Bacteremic spread of the Gram-negative diplococci Neisseria gonorrhoeae. History
Diagnosis and Management ... Arthritis-Dermatitis syndrome ... Purulent Arthritis Syndrome ... : • Most patients ... #Microbiology #InfectiousDiseases
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... ) (e.g. lupus, CLL ... antibiotics are the most ... spherocytosis) • Infections
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
++: Hodgkin, T-cell ... lymphoma, B-cell ... chemotherapy, anti-CD20 (PTLD ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... Internal (RBC) - Infections ... Defects: Sickle cell ... Peripheral Blood Smear ... Differential #Diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute infection ... sarcoidosis) • Post-splenectomy ... Myelodysplastic syndrome ... myeloid leukemia (CML ... Diagnosis #Causes #hematology
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