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differential management algorithm anemia leukemia agglutinin aplastic chronic classification cll cold diffuse disease gap globulin hemolytic hemophagocytic heon hepatitis hepatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Infectious • EBV ... Fatigue • Acute ... Reed-Sternberg Cells ... #Hematology #Oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... and petechiae Causes ... Parvovirus B19 - EBV ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
Lymphocytopenia DIAGNOSTIC ... T-cell count of 300 cells ... EBV. CMV. ... #hematology #Differential ... #Causes #lymphocytopenia
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... Drugs, Unknown cause ... treatment #summary #rheumatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular Causes ... HBV, HCV, HEV, EBV ... #differential #diagnosis ... #algorithm #hepatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... surface molecules: CD5 ... ’s lymphoma or acute ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- Blood & BM • ... • Cytopenia -> BM ... -> AML: Blast crises ... #Leukemia #Hematology ... #Oncology #Diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
hemolysis • C3↓ C4 ... - Mycoplasma, EBV ... Hemoglobinuria (PCH ... sensitize red blood cells ... hemolytic #anemia #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Hodgkin Lymphoma Workup ... lymph node biopsy (diagnostic ... classification #hematology ... #oncology #management
When to look for clonal/neoplastic hypereosinophilia (HEo)? - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
Exclusion of frequent causes ... - Myelogram/BM ... hypereosinophilia #HEON #Diagnosis ... #Signs #Hematology ... #Workup
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