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diagnosis hematology management oncology classification cns disease neurology vasculitis adultonset agglutinin aids antibodies aplastic associations autoantibodies autoimmune bandemia causes cbc
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Neutropenia - recurrent infections ... to repair DNA, as ... Idiopathic • Infections ... index < 2 • EPO Level ... #oncology #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Grafts, Valves, AS ... Drug-associated, PCH ... Defects, Drugs, Liver ... Internal (RBC) - Infections ... Defects: Sickle cell anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... - Mycoplasma, EBV ... younger pts) Differential ... Disorders Such As ... #hematology #diagnosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anti-mitochondrial (AMA ... biliary cirrhosis (PBC ... Celiac disease Anti-GBM ... diseases #diagnosis #table ... #rheumatology #
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... fraction < 20% Differential ... Diaqnoses: • Infectious ... Coxsackie, CMV, EBV ... management #treatment #rheumatology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Neutrophil (Normal) Differential ... tachycardia or fever ... science/article/abs ... /pii/S0735675715001795 ... #differential #
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... virus • CMV • EBV ... /l is regarded as ... rav7ks #CNS #Infections ... #differential #
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
HIV / AIDS - Differential ... • Symptoms: AMS ... symptoms such as ... effect/Edema • EBV ... #differential #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... procedures - Infection ... changes), high MCV anemia ... When do you do a BM ... Causes #Workup #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
cells - Blood & BM ... • Cytopenia -> BM ... Headaches, bone pain, fever ... - infiltrates (anemia ... #Leukemia #Hematology
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