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diagnosis hepatology algorithm lfts rheumatology transaminitis acute antibodies associations autoantibodies autoimmune causes comparison diseases gap globulin hepatocellular lymphoma myopathy myositis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute Liver ... Injury - Differential ... Hepatocellular - Liver ... C, A, E, B, D, EBV ... #Injury #Differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... HBV, HCV, HEV, EBV ... #injury #hepatitis ... #differential #
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... normal - Infection (EBV ... #Patterns #Liver ... #Injury #hepatology ... transaminitis #differential
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... Injury Differential ... A/B/C/D/E, EBV, ... #Injury #Differential
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g., HIV), EBV ... the spleen or liver ... lymphadenopathy, mass ... • Other hematologic ... #hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
SLE, autoimmune hepatitis ... Dermatomyositis Anti-LKM (liver ... ) - Autoimmune hepatitis ... biliary cirrhosis (PBC ... Celiac disease Anti-GBM
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... , PBC, PSC, Viral ... Gap #ProteinGap #differential ... #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... • ANA < 20 % IBM ... Other Diseases: • PBC ... , autoimmune hepatitis ... #differential #
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