21 results
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
PT (INR), Normal ... , Normal PT (INR ... #Diagnosis #Algorithm ... #Causes #Hematology ... #coagulation #disorders
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... for decreased PLT ... for decreased PLT ... : INR/PT, aPTT(liver ... #hematology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... , PT, PTT (diff ... count and platelet ... could also be seen in ... #disorders #hematology
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Differential Diagnosis Algorithm ... < 1800/uL, • platelet ... /uL Initial Workup ... iron studies, PT ... #hematology #workup
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... /PTT • Low plasma ... /INR: ↑ • PTT: ... Schistocytes, helmet cells ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
platelets == ... characteristic of a platelet ... == NORMAL PT ... /NORMAL PTT: • ... Differential #Diagnosis #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
inherited bleeding disorder ... Laboratory • Normal platelet ... 2B) • Normal PT ... /INR • Normal ... Disease #Diagnosis #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
• Sickle cells ... Consider sickle cell ... with or without platelet ... Consider RBC membrane disorder ... #workup #hematology
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Mean corpuscular (cell ... Red cell distribution ... (BM) ablative disorders ... #Diagnosis #Workup ... #Hematology #Microcytic
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Disorders • Nutritional ... Workup: • Complete ... Syndromes #diagnosis #hematology