1984 results
Hypoxia and Hypoxemia - Overview
Hypoxia - insufficient oxygen delivered to tissues to meet demands
Hypoxemia - low
O2 is inspired) PAO2 ... reaches the alveoli) PaO2 ... Low SvO2 → Low PaO2 ... sepsis) - High PaO2 ... #differential #diagnosis
Markers of Organ Dysfunction in Severe Sepsis 
Altered consciousness 
Confusion 
Psychosis 

Tachycardia 
Hypotension 
Altered CVP 
Altered
Altered CVP Altered PAOP ... Tachypnoea PaO2 ... 90% PaO2/FiO2 300% ... Protein C #Diagnosis ... #CriticalCare #Diagnosis
Approach to the A-a Gradient
A-a gradient = PAO2 - PaO2
A-a gradient = [FiO2 x (Patm -
A-a gradient = PAO2 ... - PaO2 A-a gradient ... /0.8)] - PaO2 Simplified ... /0.8)] - PaO2 Normal ... #differential #diagnosis
Berlin Criteria for Acute Respiratory Distress Syndrome (ARDS) 
- Respiratory symptoms must have begun within one
- Respiratory symptoms ... new or worsening symptoms ... - 200 mm Hg < PaO2 ... - 100 mm Hg < PaO2 ... Definition #Criteria #Diagnosis
Acid-Base Disorders - Differential Diagnosis Algorithm
Acidemia (pH < 7.35)
 • Metabolic Acidosis (HCO3 < 24mmol/L) CO2
- Differential Diagnosis ... Algorithm Acidemia ... Respiratory Acidosis (pCO2 ... #Differential #Diagnosis ... #Algorithm #Causes
Platypnea-Orthodeoxia Syndrome on Physical Exam
The case of a patient with a diagnosis of cirrhosis and platypnea-orthodeoxia
patient with a diagnosis ... Symptoms occur when ... there is a drop in SaO2 ... to 90% (and in paO2
Hepatopulmonary Syndrome
HPS - Diagnosis:
 1. Patients with liver disease
 2. Alveolar-arterial oxygen gradient (AaP02) >15 mmHg
Syndrome HPS - Diagnosis ... Moderate HPS: ≥ 60 PaO2 ... Severe HPS: ≥ 50 PaO2 ... Very severe HPS: PaO2 ... Hepatopulmonary #Syndrome #diagnosis
ABG vs VBG: Arterial vs Venous Blood Gases

ABG
PROS: Tells you exactly what the arterial environment looks
looks like (pH, PaCO2 ... Comparison #pH #pCO2 ... #Diagnosis #Differences
Non-Invasive Ventilation (BiPAP) Algorithm - Indications and Contraindications
Indications for NIV:
 • COPD - pH <7.35, pCO2
Ventilation (BiPAP) Algorithm ... COPD - pH <7.35, pCO2 ... VC < 1 even if pCO2 ... RR or daytime pCO2 ... Ventilation #BiPAP #Algorithm
Arterial Blood Gas (ABG) Analysis - Metabolic + Respiratory Acidosis + Alkalosis

pH ↓ pCO2 ↓ -
Alkalosis pH ↓ pCO2 ... acidosis pH ↑ pCO2 ... alkalosis pH ↑ pCO2 ... alkalosis pH ↓ pCO2 ... Interpretation #AcidBase #Diagnosis