1978 results
Hypoxia and Hypoxemia - Overview
Hypoxia - insufficient oxygen delivered to tissues to meet demands
Hypoxemia - low
O2 is inspired) PAO2 ... reaches the alveoli) PaO2 ... Low SvO2 → Low PaO2 ... Low SvO2 → Low PaO2 ... sepsis) - High PaO2
Approach to the A-a Gradient
A-a gradient = PAO2 - PaO2
A-a gradient = [FiO2 x (Patm -
A-a gradient = PAO2 ... - PaO2 A-a gradient ... /0.8)] - PaO2 Simplified ... Hypoventilation Syndrome ... Hepatopulmonary Syndrome
Markers of Organ Dysfunction in Severe Sepsis 
Altered consciousness 
Confusion 
Psychosis 

Tachycardia 
Hypotension 
Altered CVP 
Altered
Altered CVP Altered PAOP ... Tachypnoea PaO2 ... <70mmHg SaO2 < ... 90% PaO2/FiO2 300%
Perform computations online at:
ScyMed.com
6th ED
ICU-card
«ICU, Formulas & Drugs»
HEMODYNAMIC PATTERNS
Condition
SAP
CVP

PAP PCWP

CO C(a-v)02 PVR

SVR
Hypovolemic shock
↓
↓
↓
↓
↓
↑
↑
↑
Cardiogenic shock
↓
1
↑
1

1
↑

Septic shock
↓
↓
↓
↓
↑
↓
↓
↓
Cardiac Tamponade
.
↑
↑
1
↓

→
↑
RV
-PECO2))/PaCO2 ... age-corrected PAO2 ... /R) | Pa02 80- ... ))+(Pa02*0.0031) ... )-(CvO2) Pa02
Hepatopulmonary Syndrome
HPS - Diagnosis:
 1. Patients with liver disease
 2. Alveolar-arterial oxygen gradient (AaP02) >15 mmHg
Hepatopulmonary Syndrome ... Moderate HPS: ≥ 60 PaO2 ... Severe HPS: ≥ 50 PaO2 ... Very severe HPS: PaO2 ... Hepatopulmonary #Syndrome
ABG vs VBG: Arterial vs Venous Blood Gases

ABG
PROS: Tells you exactly what the arterial environment looks
looks like (pH, PaCO2 ... #Correlation #Comparison ... #pH #pCO2 #Diagnosis
Respiratory Oxygenation Cycle - Pathophysiology
PO2 and PCO2

By @rev.med

#Respiratory #Oxygenation #Cycle #circulation #pathophysiology
Pathophysiology PO2 ... and PCO2 By @rev.med
Hypoxemia vs Hypoxia
Hypoxemia - Partial pressure of arterial oxygen (PaO2) is below normal
Hypoxia - Insufficient oxygen
arterial oxygen (PaO2 ... compensate for low PaO2 ... differential #diagnosis #comparison
Hyperthermia Syndromes Comparison
Serotonin Syndrome - NMS - Malignant Hyperthermia - Malignant Catatonia
Cause - Onset - Vitals
Hyperthermia Syndromes ... Comparison Serotonin ... Syndrome - NMS ... #Hyperthermia #Syndromes ... #Comparison #diagnosis
Platypnea-Orthodeoxia Syndrome on Physical Exam
The case of a patient with a diagnosis of cirrhosis and platypnea-orthodeoxia
Platypnea-Orthodeoxia Syndrome ... platypnea-orthodeoxia syndrome ... there is a drop in SaO2 ... to 90% (and in paO2 ... #Orthodeoxia #Syndrome