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rheumatology differential ana antinuclear systemic abnormal autoantibodies causes coagulation patterns prolonged pt sle activation anca antibody antineutrophil arthritis classification disease
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus ( ... disease (MCTD), Drug-induced ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... erythematosus ( ... erythematosus ( ... ANA #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... SLE-Related Auto-Antibodies ... : Drug-induced lupus ... #Erythematosus ... #differential #rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... antiphospholipid antibodies ... Reduced liver synthesis ... Prolonged #Causes #diagnosis ... #differential #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... extremities Drug ... 1, SCL-70, RNP antibodies ... • Antihistone: Drug ... #Diagnosis #Rheumatology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Drugs: Direct or ... antiphospholipid antibodies ... • Reduced liver ... #differential #hematology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... erythematosus ... Anti-histone (in drug-induced ... #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... SLE (60-70%) & drug-induced ... #erythematosus ... #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus ... erythematosus [ ... ) • Sepsis • Drug-induced ... thrombocytopenia • Liver ... Activation #Syndrome #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... such as systemic lupus ... erythematosus, ... C-ANCA) pattern: antibodies ... #rheumatology #
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