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Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Donath-Landsteiner HA (paroxysmal ... Diagnosis #Table #hematology
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
, C3d ( +/- ) Paroxysmal ... Autoimmune #Hemolysis #hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
erythematosus • HLH • Paroxysmal ... Differential #Diagnosis #Hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
incompatibility • Paroxysmal ... classification #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Transfusion reaction, Paroxysmal ... differential #diagnosis #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
hemolytic anemia, Paroxysmal ... differential #diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
macroglobulinemia Paroxysmal ... hemolytic #anemia #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
marrow-failure syndromes • Paroxysmal ... Anemia #oncology #hematology
Paroxysmal Nocturnal Dyspnea

#Paroxysmal #Nocturnal #Dyspnea #PND #Pathophysiology #Diagnosis #Cardiology
Paroxysmal Nocturnal ... Dyspnea #Paroxysmal
ACUTE TREATMENT OF PAROXYSMAL SUPRAVENTRICULAR 
TACHYCARDIA 

#PSVT #Management #Cardiology #EmergencyMedicine #Treatment #Tachycardia #Supraventricular
ACUTE TREATMENT OF PAROXYSMAL