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diagnosis syndrome hematology leukemia management antimda5dm antinxp2 antinxp2dm autoimmune behcet chronic cll dermpath erythematosus lesions lupus lymphocytic myelodysplastic myopathy myositis
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... appearing during the disease ... (dermatomyositis ... #diagnosis #dermatology ... #oncology #clinical
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
Cutaneous manifestations ... severity of the disease ... #AntiMDA5 #Dermatomyositis ... #rheumatology # ... dermatology #diagnosis
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
EGPA • Solid cancers ... #semiology #signs ... #manifestations ... #pathology #lesions ... #differential
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Most common extra cutaneous ... Episcleritis Signs ... multiforme - Dermatomyositis ... #oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Manifestations: ... vasculitis) • Cutaneous ... ) Differential Diagnosis ... diagnosis #management #signs ... #symptoms #rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
in the neck Cutaneous ... auricular papules Clinical ... had more severe disease ... diagnosis #management #rheumatology ... #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... permanent alopecia Differential ... , dermatomyositis ... Induced Lupus: • Symptoms
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... syndrome: CNS manifestations ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... with no early symptoms ... Physical Exam/Signs ... Hepatomegaly • Skin ... #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... ) • Anti-Mi2 (skin ... • Anti-TIF1 (cancer-associated ... ) • Shawl sign ... Extramuscular manifestations
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