8 results
Cutaneous Manifestations of Monoclonal Gammopathy
 • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Cutaneous Manifestations ... cryoglobulinemia, Cold agglutinin ... disease, Xanthomatosis ... #dermatology #skin ... #clinical
Disorders of Pigmentations - Hypopigmentation and Hyperpigmentation - Differential Diagnosis Algorithm

HYPOPIGMENTATION
Diffuse Congenital - Generalized hypopigmentation of
Tanning • Adverse cutaneous ... • Addison's disease ... McCune Albright syndrome ... #disorders #skin ... #dermatology #Differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Syndrome (CAS): ... Viral Infection Clinical ... presentation) • Cutaneous ... younger pts) Differential ... #anemia #hematology
Skin Hyperpigmentation - Differential Diagnosis Algorithm
Diffuse:
 • Tanning
 • Adverse cutaneous drug eruption
 • Addison's disease
Skin Hyperpigmentation ... Tanning • Adverse cutaneous ... • Addison's disease ... #disorders #skin ... #dermatology #Differential
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... EGPA • Solid cancers ... #manifestations ... #pathology #lesions ... #differential
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Alpha & Mu) Skin ... Manifestations: ... gangrenosum • Cutaneous ... hypertrichosis, hyperpigmentation ... #Monoclonal #Differential
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
cryoglobulinemia Associated Disorders ... Manifestations ... cryoglobulins • Negative causes ... Biopsy: Typical pathologic ... Antiphospholipid syndrome
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Causes of Monoclonal ... gammopathy, and skin ... changes (POEMS syndrome ... Connective tissue disorders ... ovarian tumors, lung cancers