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diagnosis hematology rheumatology algorithm oncology vasculitis anemia classification cold cryofibrinogenemia cryoglobulinemia cryoglobulins dermatologic dermpath gammopathy globulin gpa granulomatosis hemolytic hypopigmentation
Cutaneous Manifestations of Monoclonal Gammopathy • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Cutaneous Manifestations ... cryoglobulinemia, Cold agglutinin ... disease, Xanthomatosis ... #dermatology #skin ... #clinical
Disorders of Pigmentations - Hypopigmentation and Hyperpigmentation - Differential Diagnosis Algorithm HYPOPIGMENTATION Diffuse Congenital - Generalized hypopigmentation of
Tanning • Adverse cutaneous ... • Addison's disease ... McCune Albright syndrome ... #disorders #skin ... #dermatology #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... Viral Infection Clinical ... presentation) • Cutaneous ... younger pts) Differential ... #anemia #hematology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... EGPA • Solid cancers ... #manifestations ... #pathology #lesions ... #differential
Skin Hyperpigmentation - Differential Diagnosis Algorithm Diffuse: • Tanning • Adverse cutaneous drug eruption • Addison's disease
Skin Hyperpigmentation ... Tanning • Adverse cutaneous ... • Addison's disease ... #disorders #skin ... #dermatology #Differential
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Manifestations: ... gangrenosum • Cutaneous ... hypertrichosis, hyperpigmentation ... Pseudohyponatremia • ↓anion gap ... #Monoclonal #Differential
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... GPA causes disease ... Rarely dominate the clinical ... reticularis Differential ... • Goodpasture syndrome
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... : • Clinical triad ... • Autoimmune diseases ... Henoch-Schönlein purpura) • Cutaneous
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... gammopathy, and skin ... changes (POEMS syndrome ... Connective tissue disorders ... ovarian tumors, lung cancers
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cryoglobulinemia Associated Disorders ... Manifestations ... cryoglobulins • Negative causes ... Biopsy: Typical pathologic ... Antiphospholipid syndrome
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