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diagnosis algorithm rheumatology vasculitis anemia classification cold comparison cryoglobulinemia cryoglobulins dermpath erythemas gammopathy gap globulin hemolytic hypopigmentation lesions oncology paraproteinemias
Cutaneous Manifestations of Monoclonal Gammopathy • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Cutaneous Manifestations ... cryoglobulinemia, Cold agglutinin ... disease, Xanthomatosis ... #dermatology #skin ... #clinical
Disorders of Pigmentations - Hypopigmentation and Hyperpigmentation - Differential Diagnosis Algorithm HYPOPIGMENTATION Diffuse Congenital - Generalized hypopigmentation of
Tanning • Adverse cutaneous ... • Addison's disease ... McCune Albright syndrome ... #disorders #skin ... #dermatology #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... Viral Infection Clinical ... presentation) • Cutaneous ... younger pts) Differential ... #anemia #hematology
Skin Hyperpigmentation - Differential Diagnosis Algorithm Diffuse: • Tanning • Adverse cutaneous drug eruption • Addison's disease
Skin Hyperpigmentation ... Tanning • Adverse cutaneous ... • Addison's disease ... #disorders #skin ... #dermatology #Differential
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Clinical Manifestations ... cryoglobulins • Negative causes ... Biopsy: Typical pathologic ... Antiphospholipid syndrome ... #hematology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... EGPA • Solid cancers ... Vasculitis #dermpath #dermatology ... #manifestations ... #differential
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Manifestations: ... gangrenosum • Cutaneous ... hypertrichosis, hyperpigmentation ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... : • Clinical triad ... • Autoimmune diseases ... Cryoglobulins: - Composed ... Henoch-Schönlein purpura) • Cutaneous
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
: infections (cutaneous ... dermal macular hyperpigmentation ... associated with cancers ... comparison #table #differential ... #diagnosis #dermatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... gammopathy, and skin ... changes (POEMS syndrome ... gastric tumors • Hematology ... #diagnosis #hematology
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