21 results
diagnosis oncology causes algorithm extravascular hemolysis hemolytic leukemia lymphocytic thrombocytosis agglutinin aplastic apml arteritis bandemia calculation cbc classification coagulation cold
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... • Sickle cell ... circulation - Infections ... immune-complex hemolytic anemia ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... G6PD deficiency) ... #Causes #differential ... #diagnosis #hematology ... #anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... anemia, Rebound ... effect from treatment ... : Chronic infections ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... malignancies • Anemia ... specifically: iron deficiency ... myeloid leukemia (CML ... Diagnosis #Causes #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
deficiencies: Iron deficiency ... defects (e.g. sickle cell ... anemia, G6PD deficiency ... Production #Index #hematology ... #anemia #differential
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... immunophenotype Clinical ... Leukemia #oncology #hematology ... #hemeonc #diagnosis ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Orange or Hep C Clinical ... • Neutropenia, anemia ... microglobulin Treatment ... workup #oncology #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... lymphoma (DLBCL, intravascular ... Cellular immune deficiency ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Clinical Presentation ... • Symptoms of anemia ... younger pts) Differential ... the RBCs causing intravascular ... #hematology #diagnosis
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
skin necrosis (at injection ... ♀, ↑Age, ESRD Pathophysiology ... D/c all heparin ... #Treatment #Hematology ... #HemeOnc
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