10 results
diagnosis rheumatology differential glomerular glomerulonephritis hematology nephrology nephrotic workup bleeding bruising c5c9deficiency classification coagulation cryoglobulinemia cryoglobulins disease gammopathy hemostasis huv
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Pathway Activation ... Formation -> Vasculitis ... #HUV #Pathophysiology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
response: The complement ... pathway is a non-specific ... alternative, or lectin pathway ... cascade -> MAC ... #pathophysiology
Review of the Coagulation Cascade Traditional Model: • Parallel extrinsic and intrinsic pathways. Contemporary Model: • 4 key
the Coagulation Cascade ... and intrinsic pathways ... Initiation phase caused ... models (i.e. common pathway ... models #hematology #pathophysiology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
the intrinsic pathway ... the extrinsic pathway ... in the common pathway ... and extrinsic pathways ... discern these causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Through 2 Different Pathways ... • Low serum C4 complement ... • Vasculitis
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... pathways. ... infections are common causes ... for ANCA-related vasculitis
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... pathways. 6) SPEP ... infections are common causes ... for ANCA-related vasculitis
Hypophosphatemia and Hypoxia - Pathophysiology ↓ Phosphate leads to ↓ red cell 2,3-DPG and a reduction
and Hypoxia - Pathophysiology ... Rapoport-Leubering pathway ... Phosphate is a cause ... renal phosphorus wasting ... respiratory #hypoxia #pathophysiology
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... Clinical Clues: ... tubulopathy) - Complement ... pathway activation ... formation causing vasculitis
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