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diagnosis differential rheumatology glomerular glomerulonephritis nephrology nephrotic pulmonary workup biostatistics bleeding bruising calculations classification cryoglobulinemia cryoglobulins disease epidemiology formulas gammopathy
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Pathway Activation ... Formation -> Vasculitis ... #HUV #Pathophysiology
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... pathways. ... infections are common causes ... for ANCA-related vasculitis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
the intrinsic pathway ... the extrinsic pathway ... in the common pathway ... and extrinsic pathways ... discern these causes
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... pathways. 6) SPEP ... infections are common causes ... for ANCA-related vasculitis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Through 2 Different Pathways ... • Low serum C4 complement ... • Vasculitis
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
• Most common cause ... Pathophysiology ... Putrid sputum/sour-tasting ... Diagnosis: • Vasculitis ... #differential #causes
Hypophosphatemia and Hypoxia - Pathophysiology ↓ Phosphate leads to ↓ red cell 2,3-DPG and a reduction
and Hypoxia - Pathophysiology ... Rapoport-Leubering pathway ... Phosphate is a cause ... renal phosphorus wasting ... respiratory #hypoxia #pathophysiology
USMLE Epidemiology and Biostatistics Summary Meta-Analysis: pools data from several studies (greater power), limited by quality/bias of
Proves cause-effect ... from a group to assess ... probability of getting ... but not on the causal ... pathway Procedure
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... Clinical Clues: ... tubulopathy) - Complement ... pathway activation ... formation causing vasculitis
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