13 results
Complement Pathways
- Classical Pathway
- Lectin Pathway
- Alternative Pathway

#Complement #Pathway #hematology #pathophysiology
Complement Pathways ... - Classical Pathway ... - Lectin Pathway ... #Pathway #hematology ... #pathophysiology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Pathway Activation ... Vasculitis #HUV #Pathophysiology ... #Rheumatology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
BEARING CHILD PATHWAY ... cell disease Rheumatology ... #Limping #NWB #Algorithm ... #Pathway #Child ... Peds #Pediatrics #Diagnosis
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin (extrinsic pathway ... FXIIa (intrinsic pathway ... #models #hematology ... #pathophysiology ... Edoxaban #heparin #pathway
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... activate inflammatory pathways ... culture used to diagnose ... Gout #Comparison #rheumatology ... #Diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... permeability Diagnosis ... • Inflammatory Pathway ... cyclophosphamide • Ischemic Pathway ... #cerebritis #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Idiopathic • Normal Complement ... #differential #diagnosis ... #algorithm #rheumatology
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
and intrinsic pathways ... models (i.e. common pathway ... Coagulation #Cascade #diagnosis ... #models #hematology ... #pathophysiology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... determine choice of pathway ... for users of the pathway ... LFTs #Abnormal #Algorithm ... #Hepatology #Liver
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
) Pathophysiology ... activate inflammatory pathways ... culture used to diagnose ... Deposition #Disease #Rheumatology ... #diagnosis #management