Pediatric Normal Lab Values diagnosis algorithm hepatology laboratory liver autoimmune - GrepMed

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Lab patterns seen in Inborn Errors of Metabolism

A table of lab values compiled from UpToDate and

Lab patterns seen ... A table of lab ... values compiled ... metabolicemergency-pathophysiology-differential-pediatrics-metabolism-algorithm-diagnosis ... Genetics #IEM #Laboratory

Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal

(LFTs) - Normal ... Values and Interpretation ... prothrombin time across labs ... #Tests #LFTs #Laboratory ... #diagnosis #hepatology

Hemolysis - Differential Diagnosis Framework

1) Environment
- Fragmentation
- MAHA: TTP, HUS, DIC, HELLP

HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Defects, Drugs, Liver ... Hypophostphatemia Laboratory ... #hematology

Clinical Diagnosis of Autoimmune Hepatitis
- Onset of jaundice within prior 8 weeks
- Ongoing consumption

Clinical Diagnosis ... of Autoimmune Hepatitis ... >1.5, and both values ... Presence of atypical laboratory ... #Hepatology #AIH

Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
• Viral
• Drugs/Toxins
•

Elevated Liver Enzymes ... Algorithm Severe ... • Ischemia • Autoimmune ... disease US — Normal ... Others #LFTs #Hepatology

Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury:
• Hepatic vein:

- Differential Diagnosis ... Algorithm Vascular ... : Autoimmune hepatitis ... - If both are normal ... #algorithm #hepatology

Hypocalcemia - Differential Diagnosis Algorithm - Low and High PTH
LOW PTH - Hypoparathyroid
- Congenital (Pediatric)

Algorithm - Low ... - Congenital (Pediatric ... disease • Autoimmune ... bypass • Liver ... rhabdomyolysis, oral

Autoimmune Hepatitis

Clinical Presentation
- Highly variable clinical presentation, from subclinical disease to acute liver failure.
-

Autoimmune Hepatitis ... disease to acute liver ... upper limit of normal ... Necrosis) If mild laboratory ... #Management #Hepatology

Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
-

- Differential Diagnosis ... Algorithm Extravascular ... Cold AIHA • Alloimmune ... Prosthetic heart valves ... #Hematology

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

and fever) and laboratory ... Differential Diagnosis ... disease • Non-autoimmune ... deficiencies • Autoimmune ... Cytopenias • Cardiac valve

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