23 results
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
IBD, Whipple's disease ... • Whipple's disease ... syndrome - SLE Neurologic ... , Vasculitis (e.g ... ENT • Oral
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... panuveitis, retinal vasculitis ... skin injury) • Neurologic ... meningitis), MCC CNS symptoms ... management #signs #symptoms
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
ANCA-positive vasculitis ... ANCA-negative vasculitis ... erythematosus, Rheumatoid arthritis ... Investigations • Labs ... differential #diagnosis #nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
and often causes arthritis ... Glomerulonephritis, arthritis ... - Recurrent oral ... Presentation - Systemic Symptoms ... retinopathy Lab
Highlighted Conditions With Arteritis or Periarteritis of the Coronaries
Takayasu's arteritis:
 - Onset < 40 yrs
 -
yrs - Cranial symptoms ... multiplex ANCA vasculitis ... Leukocytoclastic vasculitis ... Behcet's disease ... : - Oral and genital
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
sedimentation rate + Normal ... ANCA-associated vasculitis ... Cytopenias • Cardiac valve ... Induced Lupus: • Symptoms ... flares • CRP normal
Rheumatoid Arthritis - 2020 ACR-EULAR Classification
≥ 6 of 10 points = definite RA
Joint Involvement:
Rheumatoid Arthritis ... joint) - 5 points Serology ... CRP and normal ... points Duration of symptoms ... #Rheumatoid #Arthritis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... strength & enzymes normal ... affects the skin, neurologic ... • Progressive symptoms ... cognitive impairment, neurologic
Lyme Disease: Early and Late Clinical manifestations
Stage 1. Localized
 • EM appears 7-14 days at the
Lyme Disease: Early ... • Heralded by neurologic ... years after • Arthritis ... impairment - Normal ... diagnosis #signs #symptoms
Septic Arthritis - Diagnosis and Management Summary
Clinical Exam: hot, swollen, pain with passive AND active ROM
Septic Arthritis ... necrosis, Lyme disease ... evaluation • labs ... 90% sensitive in pediatrics ... (therefore oral