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rheumatology differential management systemic vasculitis classification activation bruising comparison cryoglobulinemia cryoglobulins dermatology druginduced fatigue joint laboratory macrophage mas pain peds
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... Dermatomyositis Erythema chronicum ... lesions • Discoid lupus ... #differential #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... rash • Erythematous ... lymphopenia, low PLT • Anemia ... : • Chronic B-cell ... #Diagnosis #Rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Manifestations: Malar rash ... • Immunologic Workup ... disease Dr.
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
, Vasculitis, Purpura ... of hip (rare), Arthritis ... pain (20%) Renal disease ... ) Blood (75%): Anemia ... #erythematosus #
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... (systemic lupus ... erythematosus) ... Congenital heart disease ... pediatrics #diagnosis
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... • Rheumatoid Arthritis ... • SLE • Polymyalgia ... #Algorithm #causes
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... Erythematosus ( ... • Evolution: Chronic ... disease Dr. ... #diagnosis #management
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... : - 10% SLE or ... (e.g. systemic lupus ... erythematosus (
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus ... rash) • Heart, ... SLE], AOSD) • Infection ... with leukopenia, anemia ... Activation #Syndrome #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... tract, and often causes ... mucositis - Rash ... erythematosus, ... vasculitis, and SLE
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