11 results
anemia algorithm causes oncology management purpura agglutinin bruising dermatology disease extravascular hemolysis intravascular mds monoclonal myelodysplasia myelodysplastic nonpalpable palpable paraproteinemias
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... Rebound effect from treatment ... , Vasculitides, ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic ... Non-lmmune: • HELLP Syndrome ... HUS • DIC • Vasculitis ... • Infection ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... uremic syndrome ... Extravascular #Causes #differential ... #diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... DIC/TTP/HUS - Hemolytic ... #Diagnosis #hematology ... #rheumatology #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Agglutination - Cold ... Schistocytes, thrombocytopenia ... cardiac valve, vasculitis ... inclusions - If infection ... #workup #hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Acquired - Aplastic ... - Vasculitis ... Bruising #Causes #peds ... #pediatrics #diagnosis ... #differential #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Agglutinin Syndrome ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
/fevers • Thrombocytopenia ... Idiopathic • Infections ... anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
presents with thrombocytosis ... - 30-40 years old ... ANCA-associated vasculitis ... Hypoalbuminemia Treatment ... #management #rheumatology
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