10 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
(Antineutrophil ... antibodies) • Systemic ... lupus erythematosus ... Jcortesizaguirr #ANA ... antibodies #diagnosis #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... (lupus, RA, Sjogren's ... deficiency Work ... cryoglobulins • Skin ... #Petechiae #Rash
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
causes arthritis ... mucositis - Rash ... purpura: strong sign ... LFT • ESR • ANA ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Manifestations: Malar rash ... • Immunologic Workup ... : - ANA > ... Evolution: Chronic disease
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... findings (ANA, ... 3rd Decade Skin ... Diagnosis: • ANCA-associated ... antibodies • (-) ANA
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... , mucositis • Rash ... : ANCA Associated ... causes arthritis ... Differential #Diagnosis #Rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
: - ANA > ... Discontinuation of causal ... months to years) Systemic ... : - ANA > ... Evolution: Chronic disease
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... lupus erythematosus ... classification #rheumatology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
disease. ... Episcleritis Signs ... Causes: - Idiopathic ... Leukocytoclastic vasculitis ... ’s syndrome - Lupus
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... • Anti-NXP2 (ANA ... Symptoms: • Gottron rash ... -1 antibodies (ANA ... or head drop • ANA