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diagnosis rheumatology dermatology management differential erythematosus sle photo systemic oncology skin algorithm vasculitis workup ana antinuclear autoantibodies classification disease druginduced
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of Systemic Lupus ... Photosensitivity, Butterfly rash ... Demyelinating syndromes ... ) Blood (75%): Anemia
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Diseases: • Systemic lupus ... Differential #Diagnosis #Hematology
Sweet’s Syndrome - Acute febrile neutrophilic dermatosis The syndrome involves fever, painful rash, neutrophilic leukocytosis, and
Sweet’s Syndrome ... fever, painful rash ... #Sweets #Syndrome ... neutrophilic #dermatosis #dermatology ... #Rash #Skin #Clinical
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
Erythematosus Clinical ... Immunologic Criteria CLINICAL ... NEUROLOGIC - HEMOLYTIC ANEMIA ... absence of hemolytic anemia ... #Diagnosis #Rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... Sarcoidosis #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Malignancy (e.g. hematologic ... Clinical Features ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... 69% - Malar rash ... - Hemolytic anemia ... Diagnosis and Lupus ... #differential #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... Petechial or purpuric rash ... SJIA], systemic lupus ... with leukopenia, anemia ... Diagnosis #Management #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology ... #anemia
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... : • Common Clinical ... vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... criteria for 1) hematologic
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