12 results
Algorithm for Metformin Prescribing and Dosing in CKD
Dose Initiation - Immediate release:
 • Initial 500 mg
in CKD Dose Initiation ... until maximum dose ... Dose Initiation ... until maximum dose ... #CKD #pharmacology
Phosphate binders - quick reference chart of maximum daily dose. Most patients with CKD will require
maximum daily dose ... Generally, the initial dose ... phosphate levels and doses ... Hyperphosphatemia #Dose ... #Dosing #Pharmacology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
on the highest dose ... only use lower doses ... at the lowest dose ... #Pharmacology # ... #DM2 #Endocrinology
Metformin - First Line Treatment for Diabetes Type 2
• Start with initial dose of 500 mg
Start with initial dose ... daily • Adjust dose ... Increase dose gradually ... highest dose tolerable ... #Diabetes #DM2
Estimating the Total Daily Dose (TDD) of Insulin: Weight-Based Dosing
TDD in units of insulin = N
the Total Daily Dose ... (stage IV or V CKD ... Weight #Based #pharmacology ... #endocrinology ... #diabetes #DM2
Diabetes Mellitus Type 2 Inpatient Medication Guide

Classes: Biguanide, Sulfonylurea, TZD, DPP-4 inhibitor, GLP-1 receptor agonist, SGLT2i,
Calculate total daily dose ... Adjust insulin dose ... #Mellitus #DM2 ... #comparison #table ... #endocrinology
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... oral agent • Does ... #Metformin #Pharmacology ... #Summary #DM2 # ... diabetes #endocrinology
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
increase in the dose ... an increase in dose ... ml/min per 1.73 m2 ... evidence-based pharmacologic ... #Diabetes #CKD #
Insulin Calculations for Type 1 Diabetes 

Insulin-to-Carb Ratio (ICR) 500/TDD = #g of carbs covered by
calculations used in dosing ... mealtime insulin dose ... normal mealtime dose ... #DM1 #Pharmacology ... #Endocrinology
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist
Dosing:
3 mg daily x 30 days, then 7 mg
mg maintenance dose ... smaller starting dose ... the maintenance dose ... the maintenance dose ... Endocrinology