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differential oncology causes hemolysis hemolytic leukemia chronic intravascular agglutinin algorithm cold common cvid erythematosus hemeonc hodgkins hypogammaglobulinemia immunodeficiency immunology lupus
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... (AIHA) "Warm" ( ... ) (e.g. lupus, CLL ... (AIHA)"Cold" (usually ... #hematology #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... • Alloimmune ... • Sickle cell ... immune-complex hemolytic anemia ... Algorithm #Causes #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... cytopenias (ITP, AIHA ... chemotherapy for low-risk disease ... Leukemia #oncology #hematology ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Diagnosis: • ... cells can indicate disease ... • Neutropenia, anemia ... workup #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... /Cytopenias • AIHA ... #Leukemia #Hematology ... #Oncology #Diagnosis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... Causes: • Liver disease ... Hypersplenism • AIHA ... #causes #classification ... #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Membrane): - Autoimmune ... Defects: Sickle cell ... anemia, Thalassemias ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Viral infection, autoimmune ... (older) • Autoimmune ... the RBCs causing intravascular ... #hematology #diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... Granulomatous lymphocytic ... hemolytic anemia ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... number of sites of disease ... #classification ... #hematology #oncology ... #management
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