14 results
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Warm vs Cold Autoimmune ... , Autoimmune disorder ... Autoimmune Hemolytic ... #Anemia #hematology ... #diagnosis #comparison
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... - Differential Diagnosis ... Table Warm AIHA ... Agglutinin Disease ... #Table #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... (AIHA)"Cold" (usually ... (e.g. primary cold ... lymphoproliferative disorders ... #hematology #anemia
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... esp if severe disease ... azathioprine Cold ... #management #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral infection, autoimmune ... disorder or lymphoid ... Diagnosis: • hemolytic ... CLL (older) • Autoimmune ... #hematology #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Agglutination - Cold ... Consider RBC membrane disorder ... elliptocytosis, autoimmune ... Algorithm #workup #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Unstable hemoglobin disorders ... Cell Agglutinate: Cold ... autoimmune hemolytic ... #differential #diagnosis ... #hematology #microscopy
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
and Management ... thrombocythemia), Autoimmune ... disease • vWF ... #Management #treatment ... #hematology #differential
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Advanced Liver Disease ... disorders (e.g. ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
associated with autoimmune ... cryoglobulinemia Associated Disorders ... Cryofibrinogenemia Diagnosis ... Cryofibrinogenemia #diagnosis ... hematology