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oncology anemia intravascular lymphocytic thrombocytosis algorithm aplastic arterial basophils bruising common cvid dic disseminated embolism erythematosus extravascular gap globulin hemeonc
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... : • Chronic myeloid ... leukemia (CML) ... Diagnosis #causes ... #hematology #basophils
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... extramedullary disease ... -> Invade Skin: ... #Hematology #Oncology ... #Diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelogenous Leukemia ... • Rheumatic disorders ... • Celiac disease ... effect following treatment ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
inflammatory disorders ... Myelodysplastic syndrome ... myeloid leukemia ... #Diagnosis #Causes ... #hematology #secondary
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
, coagulation disorders ... disorders CAUSES ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... cells can indicate disease ... microglobulin Treatment ... #CLL #Chronic ... #oncology #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... • Severe Liver Disease ... #diagnosis #causes ... #treatment #management ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... in adults • Disorder ... chemotherapy for low-risk disease ... #hematology #hemeonc ... #diagnosis #management
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Diagnosis Framework ... gingivitis or gingival leukemic ... von Willebrand syndrome ... discern these causes ... #Diagnosis #Hematology
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