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oncology causes chronic classification workup common cvid enlarged extravascular gap globulin hemeonc hemolysis hodgkins hypogammaglobulinemia immunology intravascular lymphoma lymphomas lymphoproliferative
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... • Rheumatic disorders ... • Celiac disease ... Diagnosis #Algorithm ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... Chronic myeloid leukemia ... #hematology #secondary
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Diagnosis Algorithm ... • Lymphoma • Leukemia ... Cell Disease (children ... #Diagnosis #Algorithm ... #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> Invade Skin: ... Leukemia (CLL) ... #Hematology #Oncology ... #Diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... , deficiency anemia ... #Diagnosis #Algorithm ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... intravascular coagulation ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... cells can indicate disease ... • Neutropenia, anemia ... #Leukemia #diagnosis ... workup #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... in adults • Disorder ... chemotherapy for low-risk disease ... #hematology #hemeonc ... #diagnosis #management
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... , coagulation disorders ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Diagnosis Algorithm ... #Anemia #Differential ... #Diagnosis #Algorithm ... #workup #hematology
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