1985 results
Raynaud Phenomenon Differential Diagnosis:

Rheumatologic

 - MCC systemic sclerosis, RA, SLE, Sjogren syndrome, Antisynthetase syndrome, MCTD
Heme

 -
Raynaud Phenomenon ... Rheumatologic - MCC systemic ... , SLE, Sjogren syndrome ... Antisynthetase syndrome ... Diagnosis #Reynaud #Phenomenon
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... rare) Raynaud's phenomenon ... joints Nervous system ... Demyelinating syndromes ... #Lupus #SLE #systemic
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... 35% • Raynaud phenomenon ... • MCTD (SLE/systemic ... polymyositis overlap syndrome
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... and Raynaud's phenomenon ... SLE-SSc-AlM overlap syndromes ... autoantibodies #Systemic
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Central nervous system ... Peripheral nervous system ... Cytopenia: 2% Systemic ... -12%), Raynaud phenomenon
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
rendering the immune system ... Paraneoplastic phenomenon ... ’s CLL Scoring system ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
processes: • Systemic ... Arthralgias • Raynaud phenomenon ... Antiphospholipid syndrome
Raynaud's Phenomenon on Physical Exam

#Raynauds #Syndrome #disease #phenomenon #clinical #video #physicalexam #fingers #hands #rheumatology
Raynaud's Phenomenon ... #Raynauds #Syndrome ... #disease #phenomenon
Systemic Sclerosis (Scleroderma)
Limited - CREST:
 • Calcinosis
 • Raynaud phenomenon
 • Esophageal dysmotility
 • Sclerodactyly
 •
Systemic Sclerosis ... Calcinosis • Raynaud phenomenon ... @AnnKumfer #Systemic
Marcus Gunn Phenomenon - Jaw Winking Syndrome

Jaw-winking syndrome is thought to be caused by abnormal innervation
Marcus Gunn Phenomenon ... - Jaw Winking Syndrome ... Jaw-winking syndrome ... #Marcus #Gunn #Phenomenon ... #Jaw #Winking #Syndrome