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Algorithm for the Diagnosis and Workup of Hemolytic Anemia

By Dr. Kylie Adamek @KylieAdamek

#Hemolytic #Anemia #Algorithm #Differential
and Workup of Hemolytic ... KylieAdamek #Hemolytic ... Anemia #Algorithm #Differential ... Diagnosis #Workup #Hematology ... #Hemolysis
Anemia - Hemolysis Diagnostic Algorithm
Autoimmune hemolytic anemia
Microangiopathic hemolytic anemia
Probable thalassemia

Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Algorithm Autoimmune hemolytic ... Microangiopathic hemolytic ... Anemia #Algorithm #hematology ... #diagnosis #differential
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... - Differential ... of anemia and hemolysis ... #Anemias #Differential ... Diagnosis #Algorithm #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - Differential ... Diagnosis Table ... #Diagnosis #Table ... #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... fragmentation hemolysis ... #schistocytes #differential ... #diagnosis #hematology ... #hemolysis
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Cold Autoimmune Hemolytic ... Warm Autoimmune Hemolytic ... Cold Autoimmune Hemolytic ... #Anemia #hematology ... #diagnosis #comparison
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... haptogbbulin #Hemolysis ... #Hemolytic #Anemia ... #Algorithm #Differential ... Causes #Workup #Hematology
Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
 • Membrane
 • Internal
    - Hemoglobin
Causes of Hemolytic ... Anemia - Differential ... Sophia_Hayes_MD #Hemolytic ... #Anemia #Differential ... Diagnosis #Causes #hematology
Bullous pemphigoid and pemphigus vulgaris

Comparison Table via Physical Examination, Nikolsky Sign and Differential Diagnoses

#Diagnosis #Dermatology #Bullous
pemphigus vulgaris Comparison ... Table via Physical ... Nikolsky Sign and Differential ... #Diagnosis #Dermatology ... #Comparison #Table
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... disease (diverse genotypes ... #Anemia #Differential ... Algorithm #workup #hematology