20 results
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
ANTI-MDA5 DERMATOMYOSITIS ... ulcerations • Skin ... ulcerations • Auricular skin ... Features of Anti-MDA5 Dermatomyositis ... 50% of cases • Skin
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... processes occur in the skin ... regeneration, diffuse CD8 ... flexors affected #Dermatomyositis ... PM #Diagnosis #Pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
tunnel, OSA, Incr skin ... #FeedbackLoop #endocrinology ... #pathophysiology
Leishmaniasis Life Cycle
1) Sandfly takes a blood meal (injects promastigote stage into the skin)
Human Stages:
2) Promastigotes
stage into the skin ... LifeCycle #diagnosis #pathophysiology ... infectiousdiseases #cdc
Calcium homeostasis is a process controlled by chiefly by hormones vitamin D and PTH. 
Vitamin D
synthesis in the skin ... #Pathophysiology ... #Endocrinology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Syndrome) is a skin ... inflamed or blistered skin ... development of skin ... multiforme - Dermatomyositis ... - CBC may also
Clonorchiasis - Clonorchis sinensis Life Cycle
1) Embryonated eggs passed in feces.
2) Eggs ingested by the snail
encyst in the skin ... Metacercariae in flesh or skin ... LifeCycle #diagnosis #pathophysiology ... infectiousdiseases #cdc
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
cold & mottled skin ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
, hair growth, skin ... tags, skin thickening ... malignancy Pathophysiology ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
weakness without skin ... polymyositis, dermatomyositis ... resolve after DC ... resolve after DC