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diagnosis hematology anemia workup causes hemolytic anemias bony calculation classification hodgkins index lymphoma macrocytic management microcytic monoclonal msk pancytopenia paraproteinemias
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Diagnosis Algorithm ... bilirubin • ↑ Reticulocytes ... #Diagnosis #Algorithm ... #hematology
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Pancytopenia - Differential ... Diagnosis Algorithm ... ↑ Destruction (hemolysis ... #Diagnosis #Algorithm ... #hematology #workup
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic Algorithm ... acute blood loss, hemolysis ... Low in bone marrow ... suggests appropriate bone ... Diagnosis #Workup #Hematology
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... hyperplasia of bone ... #Algorithm #Differential ... Causes #Workup #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Reticulocyte Production ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... Production #Index #hematology ... #anemia #differential
Primary Bone Tumors - Differential Diagnosis Algorithm Metastatic - Most common tumour in adults - Breast
- Differential ... Diagnosis Algorithm ... #Diagnosis #Algorithm ... #Orthopedics #Causes ... #Oncology #Radiology
General Approach to Anemia - Differential Diagnosis Framework 1) Check reticulocyte count to determine if hypo/hyper-proliferative 2) Exclude
Approach to Anemia - Differential ... Framework 1) Check reticulocyte ... hyper-proliferative 2) Exclude hemolysis ... #diagnosis #hematology ... #algorithm #reticulocyte
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Splenic Marginal Zone ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... Immunohistochemical studies (to differentiate ... anymore • Routine bone ... classification #hematology ... #oncology #management
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