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diagnosis erythematosus management sle differential signs symptoms ana antinuclear autoantibodies behcet classification cryofibrinogenemia disease monoclonal oncology paraproteinemias sjogrens summary table
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... defect (rare) Raynaud's ... Demyelinating syndromes ... Thrombocytopenia #Lupus ... symptoms #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... #Lupus #Erythematosus ... Summary #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... with MCTD and Raynaud's ... SLE-SSc-AlM overlap syndromes ... autoantibodies #Systemic ... #diagnosis #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
neuropathy) • Systemic ... Hypergammaglobulinemic macular ... to cold IgG • Lupus ... vascular beds-renal, retinal ... Paraproteinemias #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Erythematous, macular ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... #Diagnosis #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... ulceration • Ocular ... disease (panuveitis, retinal ... : Giant retinal ... signs #symptoms #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
processes: • Systemic ... Arthralgias • Raynaud ... thrombi including retinal ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... ulcers, cutaneous, ocular ... • Cogan Syndrome ... lupus erythematosus ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
gland) biopsy • Ocular ... Central nervous system ... Nephrogenic DI Hematologic ... Cryoglobulinemia (4%-12%), Raynaud ... #Rheumatology #
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