15 results
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
that Impair Renal Potassium ... Aldosterone Release: ACE ... Decreased Na, K-ATPase ... #Hyperkalemia #Pathophysiology ... #Pharmacology #
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... Increased EC shift of K ... differential #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Lisinopril - ACE inhibitor used for the treatment of hypertension and heart failure. 3rd most prescribed
Lisinopril - ACE ... #Pharmacology #Lisinopril ... Prinivil #Qbrelis #ACEI ... Inhibitor #Overview #Review
Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS)

This is a very common pathway that clinicians should
Here’s a review ... classes (Aliskiren, ACEI ... Antagonists), all ... , just like all ... ReninAngiotensinAldosteroneSystem #RAAS #Pharmacology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... 1) Na/K ATPase ... CaitEKulig #Digoxin #Pharmacology ... #Pathophysiology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• Digoxin • K ... • NSAIDs • ACE ... • Recent IV potassium ... K supplement 3 ... diagnosis #causes #potassium
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• Digoxin • K ... • NSAIDs • ACE ... • Recent IV potassium ... K supplement 3 ... diagnosis #causes #potassium
Veltassa (Patiromer) 
MECHANISM: Potassium Binder 
INDICATION: Treatment of Hyperkalemia 
FORMULATION: Powder for oral suspension 
DOSING: 8.4
) MECHANISM: Potassium ... needed, based on K ... patiromer) is a potassium ... ACE inhibitors, ... #Hyperkalemia #Pharmacology
Emergent Hyperkalemia Treatment Algorithm
ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
changes, weakness, K+ ... insufficiency with K ... membrane Shift K+ ... treatment Remove potassium ... offending agent (ACE-I
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
creatinine, & serum K+ ... the dose of an ACEi ... Continue ACEi or ... Statements: All ... evidence-based pharmacologic