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differential causes management algorithm rheumatology systemic anemia disorders erythematosus lupus secondary sle treatment abscess acquired antibodies associations autoantibodies bleeding bonestrength
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g ... warfarin, DOACs (e.g ... Autoimmune disorders (e.g ... #comparison #diagnosis ... #hematology #deficiency
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Toxic Damage (e.g ... Displacement (e.g ... Non-lmmune: • HELLP Syndrome ... Foreign Surface (e.g ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... G6PD deficiency) ... #hematology #anemia
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
clotting factor deficiency ... factor activity (e.g ... clotting test (e.g ... Mixing #Study #diagnosis ... #hematology #pathophysiology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential Diagnosis ... specifically: iron deficiency ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... #Causes #hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
La) - Sjogren's syndrome ... - Vasculitis, e.g ... - Vasculitis, e.g ... Associations #diseases #diagnosis ... #table #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... • Dietary Deficiency ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... Algorithm #Causes #Hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... : • Pathophysiology ... unless worrisome EKG ... #TLS #diagnosis ... #management #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Spoon-shaped • Iron deficiency ... halt nail growth (e.g ... • Nephrotic syndrome ... Systemic #Secondary #dermatology ... #Differential #Diagnosis
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Bernard-Soulier Syndrome ... a storage pool deficiency ... Platelet #Defects #comparison ... #table #differential ... #diagnosis #hematology
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