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management hematology oncology abscess autoimmune causes differentiation encephalopathy erythematosus hemeonc hemophagocytic hlh leukostasis lung lupus lymphohistiocytosis lysis mds myelodysplasia myelodysplastic
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... Prednisone 5mg/kg ... : >3 symptoms, or ... initiation • Differential ... #APML #diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... : • Pathophysiology ... unless worrisome EKG ... #TLS #diagnosis ... #management #hematology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... survival is 93-95% Pathophysiology ... at the time of diagnosis ... (e.g. incidental ... Self-limiting, chronic but stable
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess Pathophysiology ... residual lesion or is clear ... Lung Abscess Differential ... Vasculitis (e.g. ... Abscess #pulmonary #differential
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... Neurological symptoms ... Reversible course Differential ... Diagnosis: • ... • EEG: With persistent
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... transformation to AML ... blood count with differential ... progression to AML ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Non-autoimmune rheumatologic ... Induced Lupus: • Symptoms ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... patients with the HLH syndrome ... Common Signs and Symptoms ... Pathophysiology ... #Management #Hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Diagnosis Framework ... Aldolase levels • EMG ... RP-ILD), dermato-rheumatologic ... #differential #
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