54 results
Laboratory methods for evaluation of coagulation disorders- primary and secondary hemostasis

#Laboratory #Testing #Hemostasis #Coagulation #Hematology
#Diagnosis
Laboratory methods ... hemostasis #Laboratory ... #Testing #Hemostasis ... #Coagulation #Hematology
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing ... Hemolytic #Anemia #Laboratory ... #Testing #workup ... #diagnosis #hematology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
Study • Clotting tests ... • Clotting tests ... Study #diagnosis #hematology ... pathophysiology #hematology ... #laboratory
Bayesian combination of 4T score with Heparin PF4 antibody titer to obtain the post-test probability of
obtain the post-test ... Bayesian #Diagnosis #Hematology ... Thrombocytopenia #Laboratory
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Abnormal Coagulation Tests ... Abnormal #APTT #Laboratory ... #Hematology #Diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... Liver function tests ... Diagnosis #Management #Hematology ... #Rheumatology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
• Underfilled test ... Thromboplastin #laboratory ... #hematology #diagnosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... Hypophostphatemia Laboratory ... Tests: - Haptoglobin ... Differential #Diagnosis #hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Wiskott-Aldrich syndrome ... Autoimmune Diseases: • Systemic ... Differential #Diagnosis #Hematology
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
a clinical and laboratory ... coagulation and other testing ... hemolytic #anemia #Hematology