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diagnosis differential causes management nephrology tls oncology potassium high hypokalemia algorithm classification rhabdomyolysis tumor tumorlysis uricacid acute acutekidneyinjury aki brash
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... TLS) Tumor Cell Lysis ... Hypocalcemia • Hyperkalemia ... #TLS #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: • Pathophysiology ... organ damage • Treatment ... Syndrome: • Pathophysiology ... hydration - Hyperkalemia ... treatment (no calcium
Causes of Hypokalemia - Differential Diagnosis Algorithm Increased Loss - Increased GI Loss - Increased Urinary
Causes of Hypokalemia ... Transcellular Shift ... - Refeeding Syndrome ... #Hypokalemia ... potassium #low #pathophysiology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... Intracellular Shift ... release due to cell lysis ... reaction - Tumor lysis ... syndrome - Rhabdomyolysis
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... 6L/day) • For hyperkalemia ... wandering_er #Tumor #Lysis ... #Syndrome #TLS
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... hyperuricemia, #hyperkalemia ... acutekidneyinjury #Pathophysiology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... Intracellular Shift ... release due to cell lysis ... reaction - Tumor lysis ... syndrome - Rhabdomyolysis
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... and Treatment of ... hydroxide • Hyperkalemia ... #TumorLysis #Syndrome
BRASH Syndrome B - Bradycardia R - Renal failure A - AV nodal blockade S - Shock H - Hyperkalemia Typical ECG
BRASH Syndrome ... ) BRASH Treatment ... • Aggressive treatment ... DrEricStrong #BRASH #Syndrome ... diagnosis #management #pathophysiology
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm Transcellular Shift - Appropriate renal excretion (GFR,
Causes of Hyperkalemia ... Intercellular Shift ... Transcellular Shift ... Tumor Lysis Syndrome ... • Digoxin #Hyperkalemia
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