10 results
Oxygen-Hemoglobin Dissociation Curve

Left Shift (↓ O2 unloading to tissue), Left = Lower:
 • ↓ H+ (↑
Oxygen-Hemoglobin Dissociation ... Curve Left Shift ... unloading to tissue), Left ... Temperature Right Shift ... #Curve #pathophysiology
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
Oxyhemoglobin Dissociation ... Curve Left ... Oxyhemoglobin #Dissociation ... #Curve #Pathophysiology ... #Left #Right #Shift
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Transcellular Shift ... Algorithm #causes #potassium ... #low #pathophysiology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... differential #diagnosis #pathophysiology ... #pharmacology #potassium
Conceptual Relationship between Volume Responsiveness and Volume Tolerance

Assessing for volume responsiveness would only tell you that
Causes of "Left ... Shift" (Decreased ... Tolerance #IVFluids #Shift ... #Differential #Pathophysiology
Pathophysiology Of Constriction
Exaggerated Ventricular Interdependence:
 • Limited Cardiac Filling due to Fixed Volume → Septum Shifts
Pathophysiology ... Volume → Septum Shifts ... Intrathoracic-lntracardiac Dissociation ... #pericarditis #pathophysiology ... #cardiology #dissociation
Hypophosphatemia and Hypoxia - Pathophysiology

↓ Phosphate leads to ↓ red cell 2,3-DPG and a  reduction
and Hypoxia - Pathophysiology ... 2,3-DPG which shifts ... the oxygen dissociation ... curve to the left ... curve to the left
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Left Shift: • ... bands being on the left ... Metamyelocyte (Left ... Shift) → Segmented ... CBC #hematology #pathophysiology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Monitor potassium
Uncommon Causes of Noncardiogenic Pulmonary Edema (NCPE) - Differential Diagnosis Framework

High Altitude Pulmonary Edema:
 • Accumulation
epilepticus • Pathophysiology ... : The shift of fluid ... No evidence of left ... The predominant pathophysiologic ... • Pathophysiology