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diagnosis differential hematology vasculitis classification management sle cardiology champs comparison complement cryoglobulins diffuse druginduced enlarged glomerulonephritis hypocomplementemia isolated lad low
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Mnemonic C - Cryoglobulinemia ... S - Systemic Lupus ... Erythematosus ( ... #differential #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Manifestations: Malar ... Positive in 60-80% of cases ... #Systemic #Erythematosus ... Management #Summary #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Differential Diagnosis Algorithm ... Inflammatory • Systemic Lupus ... Erythematosus ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
causing endothelial injury ... • They can cause ... (e.g. systemic lupus ... erythematosus ( ... classification #rheumatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Differential Diagnosis Algorithm ... • Systemic Lupus ... Erythematosus ... #Causes #Hematology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
Causes of Isolated ... Differential Diagnosis Algorithm ... Destruction • Systemic Lupus ... Erythematosus ... #Causes #Hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... Nephritis, Cryoglobulinemia ... differential #diagnosis #algorithm ... #rheumatology
Causes of Pericarditis - Differential Diagnosis Algorithm Viral: • Coxsackie • Echovirus • Adenovirus • Epstein-Barr virus
Causes of Pericarditis ... Differential Diagnosis Algorithm ... arthritis • Systemic lupus ... erythematosus ... • Post-cardiac injury
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Discontinuation of causal ... Erythematosus ( ... Manifestations: Malar ... comparison #table #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... such as systemic lupus ... erythematosus, ... differential #diagnosis #rheumatology
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