21 results
diagnosis differential hematology management hemolytic workup erythematosus oncology sle systemic algorithm arthritis classification product reactions signs symptoms treatment abscess agglutinin
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
• Peripheral blood ... malignancy, autoimmune disease ... Recent travel/Fevers ... Malaria, Clostridium ... Diagnosis #Algorithm #causes
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... suspected, consider malaria ... bartonella (oroya fever ... ARUPLabs #Hemolytic #Anemia ... #testing
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... rash 40% - Fever ... - Hemolytic anemia ... sclerosis, Still's disease ... #differential #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... • Infections: Malaria ... Extravascular #Causes ... #anemia
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: Fever ... pain (20%) Renal disease ... Glomerulonephritis Myositis(5%) Blood ... (75%): Anemia ( ... symptoms #diagnosis #rheumatology
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
No hemolytic anemia ... Babesiosis • Plasmodium ... renal function • Blood ... a chest film; blood-smear ... and possibly PCR testing
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
plateletcount), peripheral blood ... smear, HIV/HCV testing ... PT, aPTT(liver disease ... changes), high MCV anemia ... #Workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Positive Coombs testing ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... Symptoms: High fevers ... #hematology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... Non-autoimmune rheumatologic ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia ... to: Arthritis, Fever
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... • Clinical: fever ... Leishmaniosis, malaria ... • Autoimmune diseases ... treatment #summary #rheumatology
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