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diagnosis differential hematology hemolysis management product reactions algorithm classification extravascular fever infectiousdiseases intravascular transfusions travel
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... • Peripheral blood ... disease, drugs, transfusions ... Malaria, Clostridium ... Diagnosis #Algorithm #causes
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic ... Bartonella, Babesia, Malaria ... prosthetic valve • Transfusion ... classification #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Crossmatch - involves testing ... Causes purpura & ... false negatives on testing ... tested include: Malaria
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... Causes purpura & ... TRALI): Leading cause ... false negatives on testing ... tested include: Malaria
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... AIHA, Cold AIHA, Transfusion ... Infections/toxins: Malaria ... Defects: Sickle cell anemia ... - Peripheral Blood
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
No hemolytic anemia ... Babesiosis • Plasmodium ... renal function • Blood ... a chest film; blood-smear ... and possibly PCR testing
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