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diagnosis differential algorithm blood extravascular hemolysis intravascular management product reactions autoantibodies classification erythematosus fever infectiousdiseases mimickers signs sle symptoms systemic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgG) (e.g. lupus ... • Infections: Malaria ... differential #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Infections • Malaria ... anemia • ... Diagnosis #Algorithm #Causes ... #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic ... Bartonella, Babesia, Malaria ... #Anemia #Differential ... classification #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... suspected, consider malaria ... #Anemia #Differential ... Algorithm #workup #hematology ... #testing
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Arthritis 69% - Malar ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... #differential #rheumatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... false negatives on testing ... tested include: Malaria ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Crossmatch - involves testing ... Causes purpura & ... false negatives on testing ... tested include: Malaria ... diagnosis #management #hematology
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
No hemolytic anemia ... Babesiosis • Plasmodium ... of malaria diagnosed ... polymerase-chain-reaction (PCR) testing ... and possibly PCR testing
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